DNA Nanodevices with Selective Immune Cell Interaction and Function

DNA nanotechnology produces precision nanostructures of defined chemistry. Expanding their use in biomedicine requires designed biomolecular interaction and function. Of topical interest are that function as vaccines with potential advantages over nonstructured nucleic acids terms serum stability selective human immune cells. Here, we describe how compact nanobarrels bind a 400-fold selectivity via membrane anchors to white blood cells erythrocytes, without affecting cell viability. The is based on the preference cholesterol lipid anchor for more fluid membranes compared lower fluidity erythrocytes. Compacting into gives rise increased stability. barrels furthermore functionally modulate by suppressing response pro-inflammatory endotoxin lipopolysaccharide. This likely due electrostatic or steric blocking toll-like receptors Our findings cell-specific may be applied vaccine development, immunomodulatory therapy suppress septic shock, targeting bioactive substances